Combination Therapy with Cyclophosphamide and Zymosan on a Spontaneous Mammary Cancer in Mice.
نویسندگان
چکیده
The results of experiments in which surgery, cyclophosphamide, and zymosan have been combined as therapy on a spontaneous mammary adenocarcinoma in CD8Fi fe male mice are evaluated. Zymosan, combined with cyclophosphamide and enucleative surgery, significantly enhanced the therapeutic effect. The mechanism of zymo san action as an immune phenomenon mediated by the host is considered. The data furnished additional evidence that immune phenomena may be strengthened to af ford more effective treatment in cancer and are considered of particular significance inasmuch as they were obtained with spontaneous neoplasms.
منابع مشابه
Enhanced cures of spontaneous murine mammary tumors with surgery, combination chemotherapy, and immunotherapy.
Significant numbers of cures of spontaneous mammary adenocarcinoma in CD8F, 9 (BALB/c 9 X DBA/8 Õ) mice have been effected by concomitant administration of three therapeutic modalities: surgery (enucleation) + combination chemotherapy + immunotherapy (nonspe cific immunological adjuvant). The results were obtained following lifetime observation of the animals. Immunotherapy consisted of zymosa...
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ورودعنوان ژورنال:
- Cancer research
دوره 24 شماره
صفحات -
تاریخ انتشار 1964